Humanin

Public identity

Publication state

unpublished

Sequence

Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

Available variants

Analytical boundary

Representative catalog purity: 99.5%

No active-batch certificate of analysis is currently published.

Purity figures shown here are representative catalog specifications, not lot-specific measurements.

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Evidence inventory

Record state

reviewed records

Public records

714

Reviewed summaries

67

Verified citations

0

• Human study: 141
• In vivo: 275
• In vitro: 298
• Special category: 0
• Unclassified: 0

These counts describe linked records and review status. They do not establish efficacy, safety, or fitness for any use.

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Technical record

Molecular weight

2887.4 Da

Sequence class

peptide

Appearance

Lyophilized Solid

Solubility

Water, PBS, or 0.9% NaCl

Mechanism record

Humanin is a 24-amino-acid mitochondrial-derived chemical sequence (MDP) encoded by the MT-RNR2 gene in mitochondrial 16S rRNA. It binds IGFBP-3 (reducing IGF-1 sequestration), activates FPRL1/2 formyl chemical sequence receptors, and directly inhibits BAX-mediated apoptosis by preventing mitochondrial membrane permeabilization. Cytoprotective across neuronal, vascular, and pancreatic beta-cell models.

Half-life record

~3 hours (plasma); mitochondrial retention longer

Recorded receptors

• FPRL1/2
• IGFBP-3 binding partner
• BAX inhibitor

External literature records

1. External literature record
2. External literature record

Limitations and research boundary

Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.

External records are attributed references. Their presence does not convert a source-reported observation into a product claim.