KPV

Public identity

Publication state

unpublished

Sequence

Lys-Pro-Val

Available variants

Analytical boundary

Representative catalog purity: 99.6%

No active-batch certificate of analysis is currently published.

Purity figures shown here are representative catalog specifications, not lot-specific measurements.

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Evidence inventory

Record state

reviewed records

Public records

116

Reviewed summaries

1

Verified citations

0

• Human study: 4
• In vivo: 54
• In vitro: 58
• Special category: 0
• Unclassified: 0

These counts describe linked records and review status. They do not establish efficacy, safety, or fitness for any use.

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Technical record

Molecular weight

356.4 Da

Sequence class

peptide

Appearance

Lyophilized Solid

Solubility

Water, PBS, or 0.9% NaCl

Mechanism record

KPV (Lys-Pro-Val) is the C-terminal 3-residue chemical sequence of alpha-melanocyte-stimulating hormone (α-MSH). It binds MC1R (melanocortin 1 receptor) and inhibits NF-κB nuclear translocation, suppressing transcription of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. KPV also directly inhibits inflammatory caspase activation and has demonstrated anti-microbial activity against Staphylococcus aureus and Candida albicans.

Half-life record

~30 minutes (SubQ, plasma)

Recorded receptors

• MC1R
• NF-κB inhibitory
• IL-1β/TNF-α regulation

External literature records

1. External literature record
2. External literature record

Limitations and research boundary

Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.

External records are attributed references. Their presence does not convert a source-reported observation into a product claim.