Research chemical sequence
SS-31
SS-31 is listed as a research-use-only chemical sequence. Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
Research-use boundary: Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
Public identity
- Publication state
- published
- Reviewed designation
- Elamipretide (SS-31 / Bendavia / Szeto-Schiller Peptide MTP-131)
- Designation kind
- registered
- Entity kind
- modified sequence
- Exact form
- Mitochondria-targeting tetrapeptide amide D-Arg-Dmt-Lys-Phe-NH2
- Sequence notation (three letter)
- D-Arg-dimethyl-Tyr-Lys-Phe-NH2
- Structure (other)
- CAS: 784226-00-6 | MTP-131
- Sequence
- D-Arg-dimethyl-Tyr-Lys-Phe-NH2
- IUPAC name
- (2S)-2-amino-3-phenyl-N-[(2S)-1-[[(2S)-1-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-6-aminohexanoyl]propanamide
- Molecular formula
- C32H49N9O5
Available variants
| Size | SKU | Price (USD) | Availability | Representative purity |
|---|---|---|---|---|
| 50mg | DFP-028 | $0.00 | Out of stock | 99.4% |
Analytical boundary
Representative catalog purity: 99.4%
No active-batch certificate of analysis is currently published.
Purity figures shown here are representative catalog specifications, not lot-specific measurements.
Evidence inventory
- Record state
- reviewed records
- Public records
- 497
- Reviewed summaries
- 83
- Verified citations
- 0
- Human study: 52
- In vivo: 332
- In vitro: 113
- Special category: 0
- Unclassified: 0
These counts describe linked records and review status. They do not establish efficacy, safety, or fitness for any use.
Technical record
- CAS number
- 784226-00-6
- Molecular weight
- 639.8 Da
- Sequence class
- peptide
- Molecular formula
- C32H49N9O5
- Appearance
- White to off-white lyophilized powder.
- Solubility
- Hydrophilic. SS-31 is highly soluble in aqueous solutions. For reconstitution, dissolve in sterile water or phosphate-buffered saline (PBS) at pH 7.0-7.4 to a concentration of up to 10 mg/mL. Solutions should be prepared fresh for optimal activity; avoid prolonged storage in solution, especially at room temperature.
- Mechanism record
- SS-31 (Elamipretide, D-Arg-Dmt-Lys-Phe-NH₂) is a mitochondria-targeted 4-residue chemical sequence with a D-amino acid modification enhancing protease resistance. It selectively binds cardiolipin on the inner mitochondrial membrane, stabilizing cytochrome c electron transport chain interactions, reducing mitochondrial ROS generation, and preventing cardiolipin peroxidation. In clinical trials for Barth syndrome (40mg SC daily).
- Half-life record
- ~3 hours
Recorded receptors
- Cardiolipin (inner mito membrane)
- cytochrome c stabilizer
- mito ROS scavenger
External literature records
- External literature record
- External literature record
- External literature record
Limitations and research boundary
Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
External records are attributed references. Their presence does not convert a source-reported observation into a product claim.