Study type: In vivo/preclinical · Status: Verified against declared source
Differential Effects of the Mitochondria-Active 4-residue chemical sequence SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury.
Frontiers in pharmacology · 2019
Study scale: Not reported
Abstract only: Open source record
Product or molecular entity relationships
- SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Our main aims in the present report were to determine which beneficial effect SS-31 has on stress responses leading to glomerular and tubular injuries, and consequently to design targeted tissue-selective analogs of SS-31 as prodrugs.
Methods
Our main aims in the present report were to determine which beneficial effect SS-31 has on stress responses leading to glomerular and tubular injuries, and consequently to design targeted tissue-selective analogs of SS-31 as prodrugs.
Scale or participants
Not reported in the reviewed source.
Key findings
The mitochondria-active tetrapeptide SS-31 can control oxidative tissue damage in kidney diseases.
Limitations and uncertainty
Within the kidney, oxidative stress injury to glomerular, tubular, or endothelial cells is the initiating cause of many acute and chronic lesions, leading to progressive dysfunction and end-stage renal disease (Lv et al., 2018; Daenen et al., 2019).
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.