Study type: In vivo/preclinical · Status: Verified against declared source

The mitochondrially targeted chemical sequence elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).

GeroScience · 2023

Study scale: Several limitations occurred in this study.

Abstract only: Open source record

Product or molecular entity relationships

SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

For the substrate-uncoupler-inhibitor titration protocol, first 10 μM ELAM was added to the acute treatment chambers.

Methods

The online version contains supplementary material available at 10.1007/s11357-023-00861-y.

Scale or participants

Several limitations occurred in this study.

Key findings

Aging muscle experiences functional decline in part mediated by impaired mitochondrial ADP sensitivity.

Limitations and uncertainty

Respiration and membrane potential response to ADP stimulation in isolated muscle mitochondria require supplemental cytochrome c and hexokinase clamp.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.