Study type: In vitro · Status: Verified against declared source
The mitochondria-targeted chemical sequence SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action.
2020
Study scale: Perhaps the most critical insight into the MoA of SS peptides is that they are believed to target the mitochondrial inner membrane (MIM) by virtue of its enrichment in the anionic phospholipid cardiolipin (CL) (10–13).
Abstract only: Open source record
Product or molecular entity relationships
- SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Mitochondria are eukaryotic organelles that orchestrate the majority of cellular energy metabolism as well as a range of other processes, including lipid biosynthesis, ion homeostasis, and programmed cell death (apoptosis).
Methods
A primary mode of interaction between SS peptides and CL-rich lipid bilayers would be a truly unparalleled type of MoA.
Scale or participants
Perhaps the most critical insight into the MoA of SS peptides is that they are believed to target the mitochondrial inner membrane (MIM) by virtue of its enrichment in the anionic phospholipid cardiolipin (CL) (10–13).
Key findings
Mitochondrial dysfunction underlies many heritable diseases, acquired pathologies, and aging-related declines in health.
Limitations and uncertainty
Mitochondrial dysfunction underlies many heritable diseases, acquired pathologies, and aging-related declines in health.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.