Study type: In vivo/preclinical · Status: Verified against declared source

Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats

2017

Study scale: Thousands of infants and children require prolonged periods of anesthesia when complicated surgery is needed each year.

Abstract only: Open source record

Product or molecular entity relationships

SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Effects of elamipretide pretreatment on isoflurane-induced oxidative stress in the hippocampus of developing rats.

Scale or participants

Thousands of infants and children require prolonged periods of anesthesia when complicated surgery is needed each year.

Key findings

Mitochondria are supposed to be involved in the early pathogenesis of general anesthesia (GA)-induced neurotoxicity and long-term cognitive deficits in developing brains.

Limitations and uncertainty

Mitochondria are supposed to be involved in the early pathogenesis of general anesthesia (GA)-induced neurotoxicity and long-term cognitive deficits in developing brains.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.