Study type: In vivo/preclinical · Status: Verified against declared source

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Journal of neuroinflammation · 2019

Study scale: Adult male C57BL/6 mice aged 10–11 weeks and weighing 21–23 g were purchased from Vital River Laboratories Animal Technology Co.

Abstract only: Open source record

Product or molecular entity relationships

SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Golgi–Cox staining was used to detect the dendritic spines of hippocampal neurons as described previously, with modification [36].

Methods

Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function and survival [8].

Scale or participants

Adult male C57BL/6 mice aged 10–11 weeks and weighing 21–23 g were purchased from Vital River Laboratories Animal Technology Co.

Key findings

Mice treated with LPS exhibited mitochondrial dysfunction, oxidative stress, an inflammatory response, neural cell apoptosis, and loss of dendritic spines in the hippocampus, leading to impaired hippocampus-related learning and memory performance in the MWM and contextual fear conditioning test.

Limitations and uncertainty

It is widely accepted that mitochondria have a direct impact on neuronal function and survival.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.