Study type: In vivo/preclinical · Status: Verified against declared source

Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.

Journal of neuroinflammation · 2023

Study scale: Spinal cord injury (SCI) is a devastating injury that may result in permanent motor impairment.

Abstract only: Open source record

Product or molecular entity relationships

SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

The online version contains supplementary material available at 10.1186/s12974-023-02690-4.

Scale or participants

Spinal cord injury (SCI) is a devastating injury that may result in permanent motor impairment.

Key findings

Spinal cord injury (SCI) is a devastating injury that may result in permanent motor impairment.

Limitations and uncertainty

The findings mentioned above demonstrated that under the pathological conditions of SCI, the ability of the lysosomal membrane to act as a barrier was compromised, enabling lysosomal contents to escape into the cytoplasm.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.