Study type: In vivo/preclinical · Status: Verified against declared source

Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte.

eLife · 2020

Study scale: 7) Seahorse data for the single ventricular myocytes of rats and mice are expressed in units per 800 cells.

Abstract only: Open source record

Product or molecular entity relationships

SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

2) Authors cannot claim that they have "identified ANT1 as mediating the increased proton permeability of old cardiomyocytes".

Methods

Rat cardiomyocytes were cultured with mt-cpYFP adenovirus (Wang et al., 2016b) for 3 days in M199 medium.

Scale or participants

7) Seahorse data for the single ventricular myocytes of rats and mice are expressed in units per 800 cells.

Key findings

Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population.

Limitations and uncertainty

Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.