Study type: In vitro · Status: Verified against declared source

Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2) derivatives as potent agents to ameliorate inflammation and increase mitochondrial ATP synthesis

2024

Study scale: BV2 and HT22 cell line was purchased from the Chinese Academy of Sciences Cell Bank of Type Culture Collection (Shanghai, China) and cultured in DMEM/high glucose medium containing 10% fetal bovine serum and 1% penicillin/streptomycin.

Abstract only: Open source record

Product or molecular entity relationships

SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

The BV2 cells were seeded in 12-well plates as previously described.

Methods

Traditional treatments, such as Coenzyme Q10 and MitoQ, while effective in mitigating oxidative stress, do not specifically target mitochondrial membrane components like cardiolipin.

Scale or participants

BV2 and HT22 cell line was purchased from the Chinese Academy of Sciences Cell Bank of Type Culture Collection (Shanghai, China) and cultured in DMEM/high glucose medium containing 10% fetal bovine serum and 1% penicillin/streptomycin.

Key findings

Neuroinflammation and mitochondrial function are crucial for neuronal function and survival.

Limitations and uncertainty

The mitochondrion, a membrane-bound organelle, is widespread in eukaryotic cells.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.