Study type: In vivo/preclinical · Status: Verified against declared source
The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.
eLife · 2023
Study scale: One reason for this controversy stems from a poor understanding of when, where, and how somatic mtDNA mutations arise during the normal aging process.
Abstract only: Open source record
Product or molecular entity relationships
- SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
1.
Methods
One reason for this controversy stems from a poor understanding of when, where, and how somatic mtDNA mutations arise during the normal aging process.
Scale or participants
One reason for this controversy stems from a poor understanding of when, where, and how somatic mtDNA mutations arise during the normal aging process.
Key findings
Accumulation of somatic mutations in the mitochondrial genome (mtDNA) has long been proposed as a possible mechanism of mitochondrial and tissue dysfunction that occurs during aging.
Limitations and uncertainty
Observational studies have shown that the genetic instability of mtDNA in somatic cells is a fundamental phenotype of aging and may be involved in the pathogenesis of several diseases (reviewed in Larsson, 2010).
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.