Study type: In vivo/preclinical · Status: Verified against declared source
Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice.
Frontiers in cellular neuroscience · 2020
Study scale: To detect the degree of DNA fragmentation, we performed TUNEL assays with a commercial kit (Roche TUNEL kit, Roche Molecular Biochemicals, Germany) following the manufacturer’s instructions.
Abstract only: Open source record
Product or molecular entity relationships
- SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
This study has several limitations.
Methods
EG and JW conceived and designed the experiments.
Scale or participants
To detect the degree of DNA fragmentation, we performed TUNEL assays with a commercial kit (Roche TUNEL kit, Roche Molecular Biochemicals, Germany) following the manufacturer’s instructions.
Key findings
Pyroptosis is a recently characterized inflammatory form of programmed cell death that is thought to be involved in the pathogenesis of perioperative neurocognitive disorders (PND).
Limitations and uncertainty
Pyroptosis is a recently characterized inflammatory form of programmed cell death that is thought to be involved in the pathogenesis of perioperative neurocognitive disorders (PND).
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.