Study type: In vivo/preclinical · Status: Verified against declared source
SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop.
The journal of headache and pain · 2023
Study scale: A total of 221 male C57BL/6 mice and 12 female mice weighing 20–25 g were used for this study.
Abstract only: Open source record
Product or molecular entity relationships
- SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden.
Methods
The online version contains supplementary material available at 10.1186/s10194-023-01600-6.
Scale or participants
A total of 221 male C57BL/6 mice and 12 female mice weighing 20–25 g were used for this study.
Key findings
Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden.
Limitations and uncertainty
Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.