Study type: In vivo/preclinical · Status: Verified against declared source
Comprehensive dry eye therapy: overcoming ocular surface barrier and combating inflammation, oxidation, and mitochondrial damage.
Journal of nanobiotechnology · 2024
Study scale: According to the CCK8 assay results, the highest activity of HCECs was observed after 24 h of incubation in a normal medium at a concentration of 20 µg/ml INS (Figure S8.a) and 200 µg/ml PHP-DPS@INS NPs (Figure S8.b).
Abstract only: Open source record
Product or molecular entity relationships
- SS-31: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Insulin, a hormone commonly found in the body, has been shown to exert anti-inflammatory effects [12–14].
Methods
The online version contains supplementary material available at 10.1186/s12951-024-02503-7.
Scale or participants
According to the CCK8 assay results, the highest activity of HCECs was observed after 24 h of incubation in a normal medium at a concentration of 20 µg/ml INS (Figure S8.a) and 200 µg/ml PHP-DPS@INS NPs (Figure S8.b).
Key findings
Dry Eye Disease (DED) is a prevalent multifactorial ocular disease characterized by a vicious cycle of inflammation, oxidative stress, and mitochondrial dysfunction on the ocular surface, all of which lead to DED deterioration and impair the patients’ quality of life and social functioning.
Limitations and uncertainty
Dry Eye Disease (DED) is a prevalent multifactorial ocular disease characterized by a vicious cycle of inflammation, oxidative stress, and mitochondrial dysfunction on the ocular surface, all of which lead to DED deterioration and impair the patients’ quality of life and social functioning.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.