Research chemical sequence
MOTS-c
MOTS-c is listed as a research-use-only chemical sequence. Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
Research-use boundary: Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
Public identity
- Publication state
- unpublished
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Molecular formula
- C100H152N29O20S2
Available variants
| Size | SKU | Price (USD) | Availability | Representative purity |
|---|---|---|---|---|
| 40mg | DFP-027 | $0.00 | Out of stock | 99.6% |
Analytical boundary
Representative catalog purity: 99.6%
No active-batch certificate of analysis is currently published.
Purity figures shown here are representative catalog specifications, not lot-specific measurements.
Evidence inventory
- Record state
- reviewed records
- Public records
- 401
- Reviewed summaries
- 57
- Verified citations
- 0
- Human study: 156
- In vivo: 159
- In vitro: 86
- Special category: 0
- Unclassified: 0
These counts describe linked records and review status. They do not establish efficacy, safety, or fitness for any use.
Technical record
- CAS number
- 1627580-04-1
- Molecular weight
- 2174.6 Da
- Sequence class
- peptide
- Molecular formula
- C100H152N29O20S2
- Appearance
- White to off-white lyophilized powder.
- Solubility
- Hydrophilic. Readily soluble in water (e.g., 1-5 mg/mL). For optimal stability and biological activity, reconstitute in sterile, deionized water or PBS (pH 7.0-7.4). Avoid strong alkaline solutions.
- Mechanism record
- MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived chemical sequence encoded by the 12S rRNA gene. It activates AMPK via the folate/methionine cycle (AICAR accumulation), enhancing skeletal muscle glucose uptake, fatty acid oxidation, and insulin sensitivity. MOTS-c translocates to the nucleus under metabolic stress to regulate nuclear gene expression, a mitochondria-to-nucleus retrograde signal.
- Half-life record
- ~2 hours
Recorded receptors
- AMPK activator
- AICAR folate/methionine
- skeletal muscle glucose uptake
External literature records
- External literature record
- External literature record
Limitations and research boundary
Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
External records are attributed references. Their presence does not convert a source-reported observation into a product claim.