Verified, source-grounded records

Verified studies for MOTS-c

Study records describe published research and its limitations. They do not establish efficacy, safety, or suitability for any use.

Verified study counts

194 current verified studies.

  • Human research: 0
  • In vitro: 0
  • In vivo/preclinical: 0
  • Review/meta-analysis: 0
  • Other: 0
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Current verified studies

Study type: In vivo/preclinical · Status: Citation only

Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction

2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: Human research · Status: Citation only

Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction.

Scientific reports · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice.

International journal of molecular medicine · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

Aerobic exercise and MOTS-c attenuate diabetic myocardial fibrosis via inhibition of the THBS1/TGF-β signaling pathway.

Frontiers in endocrinology · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

MOTS-c, a mitochondrial-derived chemical sequence, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation.

Autophagy · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

Exogenous MOTS-c mitigates myocardial ischemia-reperfusion injury: experimental and in silico evidence from rat heart models.

Naunyn-Schmiedeberg's archives of pharmacology · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

Therapeutic Effects of MOTS-c in the Valproic Acid-Induced Autism Model in Rats: Role of Tetrahydrobiopterin and Brain-Derived Neurotrophic Factor.

Molecular neurobiology · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

MOTS-c attenuates cardiac dysfunction following high altitude exposure by promoting mitophagy.

2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

MOTS-c preserves mitochondrial subpopulation bioenergetics and genome integrity to attenuate cardiac ischemia reperfusion injury.

Molecular biology reports · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway.

Protein and chemical sequence letters · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

MOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP1-PGAM5 interaction.

Life sciences · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: Human research · Status: Citation only

Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?

Archives of endocrinology and metabolism · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia

2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: Human research · Status: Citation only

Safety and Efficacy of Approved and Unapproved Chemical sequence Therapies for Musculoskeletal Injuries and Athletic Performance.

Sports medicine (Auckland, N.Z.) · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

A mitochondrial-derived chemical sequence MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure.

The International journal of neuroscience · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs.

BMC veterinary research · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: Human research · Status: Citation only

MOTS-c is associated with oxidative stress and arterial stiffness in peritoneal dialysis patients: a pilot study.

International urology and nephrology · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vitro · Status: Citation only

Mitochondrial-derived chemical sequences MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.

Physiological reports · 2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

Mitochondria-derived chemical sequence MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway.

2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vivo/preclinical · Status: Citation only

LAT1-mediated delivery of engineered R13A-MOTS-c attenuates radiation-induced lung injury via Nrf2 activation and mitochondrial protection

2026

Study scale: Not reported

Citation only: Open source record

Product or molecular entity relationships

  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Not reported in the reviewed source.

Limitations and uncertainty

Not reported in the reviewed source.

Citation only. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.