Study type: In vivo/preclinical · Status: Verified against declared source

Mitochondria-derived chemical sequence MOTS-c restores mitochondrial respiration in type 2 diabetic heart.

Frontiers in physiology · 2025

Study scale: In untreated diabetic rats, mass-specific oxygen flux from carbohydrate-supported substrates (including malate, glutamate and pyruvate) was 13% lower in CI + CII OXP respiratory state than in the control.

Abstract only: Open source record

Product or molecular entity relationships

MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Respirometric and fluorometric data were recorded and analysed offline using DatLab 7.1 (Oroboros Instruments).

Methods

T2D rats exhibited impaired glucose-handling ability, gained more weight compared to the control group, and developed cardiac hypertrophy.

Scale or participants

In untreated diabetic rats, mass-specific oxygen flux from carbohydrate-supported substrates (including malate, glutamate and pyruvate) was 13% lower in CI + CII OXP respiratory state than in the control.

Key findings

Type 2 diabetes (T2D) is a global epidemic, and heart failure is the primary cause of premature death among T2D patients.

Limitations and uncertainty

Type 2 diabetes (T2D) is a global epidemic, and heart failure is the primary cause of premature death among T2D patients.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.