Study type: In vitro · Status: Verified against declared source

Mitochondrial-encoded chemical sequence MOTS-c prevents pancreatic islet cell senescence to delay diabetes

2025

Study scale: Diabetes is a metabolic disorder marked by a loss of pancreatic β-cell mass and function1,2.

Abstract only: Open source record

Product or molecular entity relationships

MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

This study was approved by the Ethics Committee of Seoul National University Hospital, Korea, and all methods were performed in accordance with the relevant guidelines and regulations.

Scale or participants

Diabetes is a metabolic disorder marked by a loss of pancreatic β-cell mass and function1,2.

Key findings

Mitochondria are crucial for cell survival and function, partly through peptides encoded by the mitochondrial genome.

Limitations and uncertainty

Mitochondria possess a circular genome that was traditionally thought to host only 13 protein-coding genes.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.