VIP

Public identity

Publication state

unpublished

Sequence

His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn

Available variants

Analytical boundary

Representative catalog purity: 99.4%

No active-batch certificate of analysis is currently published.

Purity figures shown here are representative catalog specifications, not lot-specific measurements.

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Evidence inventory

Record state

reviewed records

Public records

17197

Reviewed summaries

158

Verified citations

0

• Human study: 295
• In vivo: 10187
• In vitro: 6715
• Special category: 0
• Unclassified: 0

These counts describe linked records and review status. They do not establish efficacy, safety, or fitness for any use.

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Technical record

Molecular weight

3326.9 Da

Sequence class

peptide

Appearance

Lyophilized Solid

Solubility

Water, PBS, or 0.9% NaCl

Mechanism record

Vasoactive Intestinal Chemical sequence (VIP) is a 28-amino-acid neuroactive chemical sequence that signals through VPAC1 and VPAC2 G-protein-coupled receptors. It activates adenylyl cyclase → cAMP → PKA cascades causing smooth muscle relaxation, vasodilation, and bronchodilation. VIP also modulates immune function via suppression of pro-inflammatory cytokines (TNF-α, IL-6) and promotion of regulatory T-cell differentiation.

Half-life record

~1–2 minutes (IV, plasma); longer tissue effects

Recorded receptors

• VPAC1
• VPAC2
• PAC1 partial

External literature records

1. External literature record
2. External literature record

Limitations and research boundary

Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.

External records are attributed references. Their presence does not convert a source-reported observation into a product claim.