Study type: In vitro · Status: Verified against declared source

Antioxioxidant and antiapoptotic effects of Thymosin β4 in Aβ-induced SH-SY5Y cells via the 5-HTR1A/ERK axis.

PloS one · 2023

Study scale: Not reported

Product or molecular entity relationships

Thymosin Beta-4 (TB500): Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Alzheimer’s disease (AD) is a common amnestic cognitive impairment characterised by β-amyloid (Aβ) plaques deposit in the brain of the elderly.

Methods

Total RNA was purified from SH-SY5Y cells using Trizol (Magen, China) and reverse-transcribed into cDNA using a HiFiScript cDNA synthesis kit (#CW2569M, CWbiotech, China).

Scale or participants

Not reported in the reviewed source.

Key findings

Alzheimer’s disease (AD) is a common amnestic cognitive impairment characterised by β-amyloid (Aβ) plaques deposit in the brain of the elderly.

Limitations and uncertainty

Alzheimer’s disease (AD) is a common amnestic cognitive impairment characterised by β-amyloid (Aβ) plaques deposit in the brain of the elderly.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.