Study type: In vivo/preclinical · Status: Verified against declared source
Thymosin β4 released from functionalized self-assembling chemical sequence activates epicardium and enhances repair of infarcted myocardium.
Theranostics · 2021
Study scale: Recent studies have suggested that the epicardium plays an important role in heart development as well as regeneration of the injured myocardium 10.
Abstract only: Open source record
Product or molecular entity relationships
- Thymosin Beta-4 (TB500): Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
Methods: The functionalized SAP was constituted with self-assembling motif, Tβ4-binding site, and cell adhesive ligand.
Scale or participants
Recent studies have suggested that the epicardium plays an important role in heart development as well as regeneration of the injured myocardium 10.
Key findings
Results: We found that the designer RADA-RPR bound Tβ4 and adhered to EPDCs and that Tβ4 released from the functionalized SAP could effectively activate the epicardium and induce EPDCs to differentiate towards cardiovascular cells as well as lymphatic endothelial cells.
Limitations and uncertainty
Conclusions: These results demonstrate that sustained release of Tβ4 from the functionalized SAP can activate the epicardium and effectively enhance the repair of infarcted myocardium.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.