Study type: In vivo/preclinical · Status: Verified against declared source
Human antimicrobial protein hCAP18/LL-37 promotes a metastatic phenotype in breast cancer.
Breast cancer research : BCR · 2009
Study scale: The expression of hCAP18 correlated closely with that of ERBB2 and with the presence of lymph node metastases in oestrogen receptor-positive tumours.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
The role for hCAP18/LL-37 as a proinflammatory molecule in innate immunity is well established.
Methods
Levels of hCAP18 were compared with respect to lymph node and ER status by means of analysis of variance (ANOVA).
Scale or participants
The expression of hCAP18 correlated closely with that of ERBB2 and with the presence of lymph node metastases in oestrogen receptor-positive tumours.
Key findings
hCAP18 mRNA was quantified in 109 primary breast cancers and compared with clinical findings and ERBB2 mRNA expression.
Limitations and uncertainty
Antimicrobial proteins, including hCAP18/LL-37, have primarily been proposed as potential anti-tumour agents based on their cytotoxic effects at high concentration [15,16].
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.