Study type: In vivo/preclinical · Status: Verified against declared source

Multisensory gamma stimulation promotes glymphatic clearance of amyloid.

Nature · 2024

Study scale: a, Example image of blood vessels imaged by two-photon microscopy through a cranial window using Texas Red–dextran 70 kD in 6-month-old 5XFAD mice.

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Mice had received a cranial window (3 weeks prior) and intracisterna magna implant (~3 h prior) and habituated to awake head-fixed imaging.

Methods

To test whether glymphatic clearance is associated with multisensory 40 Hz-mediated amyloid clearance, we began by monitoring CSF dynamics.

Scale or participants

a, Example image of blood vessels imaged by two-photon microscopy through a cranial window using Texas Red–dextran 70 kD in 6-month-old 5XFAD mice.

Key findings

The glymphatic movement of fluid through the brain removes metabolic waste1–4.

Limitations and uncertainty

Not reported in the reviewed source.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.