Study type: In vivo/preclinical · Status: Verified against declared source
The Escherichia coli-derived thymosin β4 concatemer promotes cell proliferation and healing wound in mice.
BioMed research international · 2013
Study scale: Tβ4 is also present in tumor cells [2], and several research groups have found that aberrant expression of Tβ4 is associated with metastasis [10] and invasion of tumor cells [3], as seen in colorectal carcinoma [17, 18], gastrointestinal stromal tumors [2], breast cancer cells [19], melanoma, and lung tumors in mouse [10].
Abstract only: Open source record
Product or molecular entity relationships
- Thymosin Beta-4 (TB500): Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
Thymosin β4 (Tβ4) is one of the most promising thymosins for future clinical applications, and it is anticipated that commercial demand for Tβ4 will increase.
Scale or participants
Tβ4 is also present in tumor cells [2], and several research groups have found that aberrant expression of Tβ4 is associated with metastasis [10] and invasion of tumor cells [3], as seen in colorectal carcinoma [17, 18], gastrointestinal stromal tumors [2], breast cancer cells [19], melanoma, and lung tumors in mouse [10].
Key findings
Thymosin β4 (Tβ4) is one of the most promising thymosins for future clinical applications, and it is anticipated that commercial demand for Tβ4 will increase.
Limitations and uncertainty
Tβ4 is also present in tumor cells [2], and several research groups have found that aberrant expression of Tβ4 is associated with metastasis [10] and invasion of tumor cells [3], as seen in colorectal carcinoma [17, 18], gastrointestinal stromal tumors [2], breast cancer cells [19], melanoma, and lung tumors in mouse [10].
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.