Study type: In vivo/preclinical · Status: Verified against declared source

Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.

Journal of neuroinflammation · 2021

Study scale: Following NORT, mice were assessed in the Y maze.

Product or molecular entity relationships

Thymosin Beta-4 (TB500): Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Thymosin β4 (Tβ4) is the most abundant member of the β-thymosins and plays an important role in the control of actin polymerization in eukaryotic cells.

Methods

The online version contains supplementary material available at 10.1186/s12974-021-02166-3.

Scale or participants

Following NORT, mice were assessed in the Y maze.

Key findings

Thymosin β4 (Tβ4) is the most abundant member of the β-thymosins and plays an important role in the control of actin polymerization in eukaryotic cells.

Limitations and uncertainty

This also applied to Sholl analysis quantification when we summarized the represented microglia profile.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.