Study type: In vivo/preclinical · Status: Verified against declared source
Top-down input modulates visual context processing through an interneuron-specific circuit.
Cell reports · 2023
Study scale: Additional experiments remain to test our model more thoroughly (Figure 7).
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Although rodent studies often use an active behavioral task during sensory processing paradigms as a strategy to ensure attention to the stimuli, here we intentionally employed a passive paradigm.
Methods
It was also apparent that 40-Hz stimulation strongly activated VIPs.
Scale or participants
Additional experiments remain to test our model more thoroughly (Figure 7).
Key findings
Visual stimuli that deviate from the current context elicit augmented responses in the primary visual cortex (V1).
Limitations and uncertainty
Interneurons can also support the generation and maintenance of cortical oscillations21 to optimize information processing22-28 and provide periodic temporal windows that gate or route long-range inputs, structuring their influence on ongoing local processing.29 For example, during active attentional tasks in non-human primates, top-down/feedback connections in the visual system exhibit activity in the alpha or beta domain (9–25 Hz), while bottom-up/feedforward and local connections exhibit oscillatory signatures in the delta/theta (3–8 Hz) and gamma (25–10 Hz) bands.30,31 Across cortical regions, DD signals appear to occupy mainly delta/theta frequencies (3–8 Hz) in visual,2,6 auditory,32 and multimodal oddball paradigms,33 supporting the hypothesis that DD signals are prediction errors that are “fed forward” in cortical networks.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.