Study type: In vitro · Status: Verified against declared source

Semax, a Synthetic Regulatory Chemical sequence, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.

ACS chemical neuroscience · 2022

Study scale: Alzheimer’s disease represents the most common neurodegenerative disease.1 According to data from the World Alzheimer Report, over 46.8 million people were affected by dementia worldwide in 2015, with a prevision of a doubling of this number in the next 20 years.2,3 To date, despite the intense research activity, the etiology of the pathology is not fully understood.

Abstract only: Open source record

Product or molecular entity relationships

  • Semax: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

The presence of Cu2+ 1:1 alone (Figure 4, orange curve) totally modifies the kinetics of fiber formation.

Methods

It has previously been shown that Aβ1–42 oligomeric aggregates form insoluble amyloid deposits in the brain and hippocampus and exhibit neurotoxic effects in in vitro and in vivo models, leading to the cognitive dysfunction prevalent in the pathogenesis of AD.82,83 Thus, to assess the cytotoxicity of the oligomeric species, the effect of Aβ1–42 at different preparations of oligomerization on the viability of d-SH-SY5Y cells was investigated via an MTT assay (Figure 6).

Scale or participants

Alzheimer’s disease represents the most common neurodegenerative disease.1 According to data from the World Alzheimer Report, over 46.8 million people were affected by dementia worldwide in 2015, with a prevision of a doubling of this number in the next 20 years.2,3 To date, despite the intense research activity, the etiology of the pathology is not fully understood.

Key findings

Alzheimer’s disease, the most common form of dementia, is characterized by the aggregation of amyloid beta protein (Aβ).

Limitations and uncertainty

Semax at an equimolar ratio (Figure 1, gray curve) does not significantly perturb any of the kinetic parameters of the Aβ1–40 fibrillogenesis process in our condition.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.