Study type: In vitro · Status: Verified against declared source
Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.
Cell death & disease · 2017
Study scale: Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%.
Abstract only: Open source record
Product or molecular entity relationships
- Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Previous studies have shown that mtDNA-deficient (Rho0) ARPE-19 cells had diminished mitochondrial membrane potential, altered expression of genes related to lipid transport, inflammation, drusen deposits and various extracellular matrix materials compared to wild-type cells.30 This indicates that the mitochondria play a role in those particular pathways.
Methods
Previous studies have shown that mtDNA-deficient (Rho0) ARPE-19 cells had diminished mitochondrial membrane potential, altered expression of genes related to lipid transport, inflammation, drusen deposits and various extracellular matrix materials compared to wild-type cells.30 This indicates that the mitochondria play a role in those particular pathways.
Scale or participants
Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%.
Key findings
Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%.
Limitations and uncertainty
Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.