Study type: In vitro · Status: Verified against declared source

Antimicrobial chemical sequence LL-37 is bactericidal against Staphylococcus aureus biofilms.

PloS one · 2019

Study scale: Primary arthroplasty, such as total knee arthroplasty (TKA), is one of the most commonly performed orthopedic procedures.

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

The goals of PJI treatment are aimed at eradicating the infection.

Methods

One promising antimicrobial agent is the antimicrobial peptide (AMP) LL-37.

Scale or participants

Primary arthroplasty, such as total knee arthroplasty (TKA), is one of the most commonly performed orthopedic procedures.

Key findings

Our current challenge in the management of prosthetic joint infection is the eradication of biofilms which has driven the need for improved antimicrobial agents and regimens.

Limitations and uncertainty

Primary arthroplasty, such as total knee arthroplasty (TKA), is one of the most commonly performed orthopedic procedures.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.