Study type: In vitro · Status: Verified against declared source
Effects of LL-37 on Gingival Fibroblasts: A Role in Periodontal Tissue Remodeling?
Vaccines · 2018
Study scale: Human cathelicidin (hCAP18) is an 18 kDa protein [1], derived from the cathelicidin family of host defence peptides, and is the only cathelicidin protein in humans [2,3].
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
Total MMP activity profiles of all individual cell supernatants were determined using the AnaSpec 520 MMP FRET Substrate XIV (AnaSpec, Fremont, CA, USA), using a method previously described by our group [20].
Scale or participants
Human cathelicidin (hCAP18) is an 18 kDa protein [1], derived from the cathelicidin family of host defence peptides, and is the only cathelicidin protein in humans [2,3].
Key findings
Mounting evidence suggests that the host defence peptide, LL-37, plays a role in both inflammation and in wound healing; however, the role of this peptide in the remodeling and maintenance of oral tissues is not yet fully understood.
Limitations and uncertainty
Mounting evidence suggests that the host defence peptide, LL-37, plays a role in both inflammation and in wound healing; however, the role of this peptide in the remodeling and maintenance of oral tissues is not yet fully understood.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.