Study type: Human research · Status: Verified against declared source

Mitochondrial stress and mitokines in aging.

Aging cell · 2023

Study scale: Various still poorly understood other communication channels through electrical and calcium signals, pH flashes or coordinated oscillations of mitochondrial membrane potentials have been reported to be implicated in inter‐mitochondrial crosstalk as well (Kurz et al., 2010; Santo‐Domingo et al., 2013).

Abstract only: Open source record

Product or molecular entity relationships

Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Mitokines are signaling molecules that enable communication of local mitochondrial stress to other mitochondria in distant cells and tissues.

Methods

Not reported in the reviewed source.

Scale or participants

Various still poorly understood other communication channels through electrical and calcium signals, pH flashes or coordinated oscillations of mitochondrial membrane potentials have been reported to be implicated in inter‐mitochondrial crosstalk as well (Kurz et al., 2010; Santo‐Domingo et al., 2013).

Key findings

Mitokines are signaling molecules that enable communication of local mitochondrial stress to other mitochondria in distant cells and tissues.

Limitations and uncertainty

While many molecules can be shuttled in smaller extracellular vesicles (usually 40–100 nm in diameter), larger extracellular vesicles of diameters >200 nm can carry mitochondrial components and even entire mitochondria (Manickam, 2022).

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.