Study type: In vivo/preclinical · Status: Verified against declared source
Proliferative enteropathy (PE)-induced changes in the calbindin-immunoreactive (CB-IR) neurons of inferior mesenteric ganglion supplying the descending colon in the pig.
Journal of molecular neuroscience : MN · 2012
Study scale: A subpopulation of the pig inferior mesenteric ganglia (IMG) neurons projecting to the colon exhibit calbindin-like immunoreactivity.
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
A subpopulation of the pig inferior mesenteric ganglia (IMG) neurons projecting to the colon exhibit calbindin-like immunoreactivity.
Methods
Standard controls, i.e., preabsorption for the neuropeptide antisera (20 mg of appropriate antigen per 1 ml of corresponding antibody at working dilution), and the omission and replacement of all primary antisera by non-immune sera or PBS were applied to test both antibody- and method specificity.
Scale or participants
A subpopulation of the pig inferior mesenteric ganglia (IMG) neurons projecting to the colon exhibit calbindin-like immunoreactivity.
Key findings
A subpopulation of the pig inferior mesenteric ganglia (IMG) neurons projecting to the colon exhibit calbindin-like immunoreactivity.
Limitations and uncertainty
The neuropeptide calbindin (CB) was first identified in the intestines of the chicken (Wasserman et al.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.