Study type: In vitro · Status: Verified against declared source
Paradoxical response reversal of top-down modulation in cortical circuits with three interneuron types.
eLife · 2017
Study scale: The strengths of the connections are rescaled so that the average input of a unit in population i from all units in population j is Wij as given in Table 1.
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
These experimental results raise two questions: First, the external activation of a population that directly inhibits a second population can trigger a positive response of the latter.
Methods
Populations are connected according to the microcircuit scheme in Figure 1a which contains the connections reported in both Jiang et al., 2015 and Pfeffer et al.
Scale or participants
The strengths of the connections are rescaled so that the average input of a unit in population i from all units in population j is Wij as given in Table 1.
Key findings
Pyramidal cells and interneurons expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP) show cell-type-specific connectivity patterns leading to a canonical microcircuit across cortex.
Limitations and uncertainty
Three major non-overlapping classes of interneurons expressing parvalbumin, somatostatin and vasoactive intestinal peptide (henceforth denoted PV, SST and VIP respectively) make up more than 80% of GABAergic cells of mouse cortex (Rudy et al., 2011).
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.