Study type: In vivo/preclinical · Status: Verified against declared source

Comparative study on the gastrointestinal- and immune- regulation functions of Hedysari Radix Paeparata Cum Melle and Astragali Radix Praeparata cum Melle in rats with spleen-qi deficiency, based on fuzzy matter-element analysis.

Pharmaceutical biology · 2022

Study scale: The method of HRPCM was optimized by our group’s previous experiments (Niu et al.

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

As two traditional Chinese herbs, HRPCM and ARPCM have long been used to treat SQD.

Methods

After the SQD model was established, the Sprague–Dawley (SD) rats were randomly divided into nine groups (n = 10): normal; model; Bu-Zhong-Yi-Qi Pills; 18.9, 12.6 and 6.3 g/kg dose groups of HRPCM and ARPCM.

Scale or participants

The method of HRPCM was optimized by our group’s previous experiments (Niu et al.

Key findings

Hedysari Radix Praeparata Cum Melle (HRPCM) and Astragali Radix Praeparata Cum Melle (ARPCM) are used interchangeably in clinics to treat spleen-qi deficiency (SQD) symptom mainly including gastrointestinal dysfunction and decreased immunity, which has unknown differences in efficacy.

Limitations and uncertainty

Hedysari Radix (HR), named ‘Hong-Qi’ in China, comes from the dry root of Hedysarum polybotrys Hand.-Mazz.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.