Study type: Human research · Status: Verified against declared source
Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection
2018
Study scale: Regulation of postsynaptic membrane potential represents a significant part of oxytocin's contribution to the modulation of synaptic function.
Abstract only: Open source record
Product or molecular entity relationships
- Oxytocin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
With regard to the defects in oxytocin signaling, there is a whole spectrum of neurodevelopmental disorders frequently associated with them, which include autism; therefore, it is increasingly important to pay attention to the role of oxytocin and its receptor in synapse structure, function, and neuron connectivity.
Methods
Even though the mechanisms are far from clear, promising results on the use of oxytocin have been produced by some research groups.
Scale or participants
Regulation of postsynaptic membrane potential represents a significant part of oxytocin's contribution to the modulation of synaptic function.
Key findings
Aberrant regulation of oxytocin signaling is associated with the etiology of neurodevelopmental disorders.
Limitations and uncertainty
Modern techniques allow for specifically tracing and optogenetically stimulating oxytocin receptor-expressing neurons in different brain regions in order to observe the effects on thirst-related neural circuits or social behavior-related circuits [13, 14].
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.