Study type: In vitro · Status: Verified against declared source
De novo design and synthesis of ultra-short peptidomimetic antibiotics having dual antimicrobial and anti-inflammatory activities.
PloS one · 2013
Study scale: Some of our designed HDAMPs exhibited potent broad-spectrum antimicrobial activity, with improved prokaryotic selectivity, and retained LPS neutralization activity in comparison to LL-37.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
Much attention has been focused on the design and synthesis of potent, cationic antimicrobial peptides (AMPs) that possess both antimicrobial and anti-inflammatory activities.
Scale or participants
Some of our designed HDAMPs exhibited potent broad-spectrum antimicrobial activity, with improved prokaryotic selectivity, and retained LPS neutralization activity in comparison to LL-37.
Key findings
In an attempt to overcome the issues described above, a set of ultra-short, His-derived antimicrobial peptides (HDAMPs) has been developed for the first time.
Limitations and uncertainty
Much attention has been focused on the design and synthesis of potent, cationic antimicrobial peptides (AMPs) that possess both antimicrobial and anti-inflammatory activities.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.