Study type: In vivo/preclinical · Status: Verified against declared source
Development of the aganglionic colon following surgical rescue in a cell therapy model of Hirschsprung disease in rat.
Disease models & mechanisms · 2023
Study scale: Growth curves of Ednrb−/− and WT rats from the Ednrb colony, showing the effect of supplementation with an oral rehydration and energy solution.
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Wholemount of the colon of a 1-week-old Ednrb−/− rat.
Methods
Up until the time of weaning, 3 weeks after the rescue surgery, KO rats that had undergone surgery grew similarly to WT rats (Fig.
Scale or participants
Growth curves of Ednrb−/− and WT rats from the Ednrb colony, showing the effect of supplementation with an oral rehydration and energy solution.
Key findings
In Hirschsprung disease, there is failure of the enteric nervous system of the distal bowel to form during development.
Limitations and uncertainty
Patients with Hirschsprung disease lack enteric ganglia in the distal colon and propulsion of colorectal content is substantially impaired.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.