Study type: In vitro · Status: Verified against declared source
Designing Analogs of SAAP-148 with Enhanced Antimicrobial and Anti-LPS Activities.
International journal of molecular sciences · 2024
Study scale: The emergence of antibiotic-resistant clinical bacterial strains has prompted a shift in research focus towards innovative classes of antimicrobial compounds.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
AMPs exhibit a diverse array of primary and secondary structures, and comprehending their structural characteristics is imperative for their advancement as therapeutic agents [13,14].
Methods
SAAP-148, a derivative of LL-37, exhibits a well-defined amphipathic structure and enhanced antimicrobial activity; however, it also displays significant cytotoxicity towards human cells.
Scale or participants
The emergence of antibiotic-resistant clinical bacterial strains has prompted a shift in research focus towards innovative classes of antimicrobial compounds.
Key findings
SAAP-148, a derivative of LL-37, exhibits a well-defined amphipathic structure and enhanced antimicrobial activity; however, it also displays significant cytotoxicity towards human cells.
Limitations and uncertainty
SAAP-148, a derivative of LL-37, exhibits a well-defined amphipathic structure and enhanced antimicrobial activity; however, it also displays significant cytotoxicity towards human cells.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.