Study type: In vitro · Status: Verified against declared source
Human antimicrobial chemical sequence, LL-37, induces non-inheritable reduced susceptibility to vancomycin in Staphylococcus aureus.
Scientific reports · 2020
Study scale: Colistin is a cationic AMP used in treatment of Gram-negative infections, however AMPs are also major components of the innate immune system and a critical defence against a large number of pathogens14.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
Antimicrobial peptides (AMPs) are central components of the innate immune system providing protection against pathogens.
Scale or participants
Colistin is a cationic AMP used in treatment of Gram-negative infections, however AMPs are also major components of the innate immune system and a critical defence against a large number of pathogens14.
Key findings
Antimicrobial peptides (AMPs) are central components of the innate immune system providing protection against pathogens.
Limitations and uncertainty
Bacterial resistance to antibiotics is generally associated with genetic changes, such as point mutations in the core genome or acquisition of resistance genes present on mobile genetic elements1, or intrinsic resistance to antimicrobials, such as impermeability of the outer membrane of Gram-negative bacteria or the active efflux of antimicrobials provided by chromosomally encoded efflux pumps2.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.