Study type: In vivo/preclinical · Status: Verified against declared source
Evidence of natural selection in the mitochondrial-derived chemical sequences humanin and SHLP6.
Scientific reports · 2023
Study scale: Location of MDPs in mtDNA.
Abstract only: Open source record
Product or molecular entity relationships
- Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
- MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
An earlier analysis of MOTS-c sequences in 14 species (13 mammals and 1 fish) claimed to show evidence of “positive” selection15.
Methods
Our evaluation of synonymous codon bias has revealed that at least two MDPs, humanin and SHLP6, show evidence of natural selection, implying these peptides have biological roles that have been important during the course of vertebrate evolution.
Scale or participants
Location of MDPs in mtDNA.
Key findings
Mitochondrial-derived peptides are encoded by mitochondrial DNA but have biological activity outside mitochondria.
Limitations and uncertainty
Mitochondrial-derived peptides are encoded by mitochondrial DNA but have biological activity outside mitochondria.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.