Study type: Human research · Status: Evidence verified by machine against declared source
Synergistic Increase of Serum BDNF in Alzheimer Patients Treated with Cerebrolysin and Donepezil: Association with Cognitive Improvement in ApoE4 Cases
The International Journal of Neuropsychopharmacology · 2016
Study scale: The present investigation was conducted in 158 patients with mild-to-moderate probable AD included in a RCT (clinicaltrials.gov number NCT00911807) that completed the study and were suitable for the per-protocol analysis.
Abstract only: Open source record
Product or molecular entity relationships
- Cerebrolysin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Public plain-language summary
Some fields are not published, because the text held for them did not answer their heading. The published text is limited to the declared source and preserves reported uncertainty. It does not establish efficacy, safety, suitability, or evidence strength.
Research question
Not reported in the declared source.
Study design
Not reported in the declared source.
Participants or experimental system
Reduced brain and cerebrospinal fluid levels of brain derived neurotrophic factor (BDNF) were found to be associated with cognitive deficits in Alzheimer’s disease (AD) patients (Peng et al., 2005; Ginsberg et al., 2006).
Study scale
The present investigation was conducted in 158 patients with mild-to-moderate probable AD included in a RCT (clinicaltrials.gov number NCT00911807) that completed the study and were suitable for the per-protocol analysis.
Intervention or exposure
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Comparator
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Outcomes examined
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Key findings
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Limitations and uncertainty
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Product relevance and evidence boundary
This record is a published study, held here with its citation and review status. It is not a statement that any catalog item is effective, safe, or suitable for any use, and nothing in it is a dose or a protocol.
Evidence verified by machine against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.