Study type: Human research · Status: Verified against declared source
The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial
2015
Study scale: This study of intranasal-administered oxytocin in young children with autism was a double-blind, randomized, placebo-controlled, crossover, clinical trial.
Abstract only: Open source record
Product or molecular entity relationships
- Oxytocin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
The first drug administration of each phase was conducted at the BMC.
Methods
The main disadvantage of a crossover study is the potential for carry-over between conditions, which confounds the estimate of effects.
Scale or participants
This study of intranasal-administered oxytocin in young children with autism was a double-blind, randomized, placebo-controlled, crossover, clinical trial.
Key findings
Interventions for autism are limited.
Limitations and uncertainty
Autism represents a group of complex brain developmental disorders characterized by impairments in social interaction, social communication and stereotypical and repetitive behaviors.1 The diagnosed incidence of autism is estimated to be 1 in 68 children.2 However, effective interventions have remained limited.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.