Study type: In vitro · Status: Verified against declared source

[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6

2024

Study scale: HUVECs were freshly isolated from individual umbilical cord veins, collected immediately after delivery (39 to 41 weeks), by collagenase digestion29.

Abstract only: Open source record

Product or molecular entity relationships

Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

The cells were cultured in normal or high glucose conditions for 24 h, 48 h, or 72 h.

Methods

The online version contains supplementary material available at 10.1038/s41598-024-81878-x.

Scale or participants

HUVECs were freshly isolated from individual umbilical cord veins, collected immediately after delivery (39 to 41 weeks), by collagenase digestion29.

Key findings

High glucose (HG) induced endothelial senescence is related to endothelial dysfunction and cardiovascular complications in diabetic patients.

Limitations and uncertainty

Humanin, the first member of identified mitochondrial derived peptides (MDPs), plays a cytoprotective role in modulation of mitochondrial function and ROS production under stressful and senescence conditions26.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.