Study type: In vivo/preclinical · Status: Verified against declared source

Mitochondrial-Derived Chemical sequence MOTS-c Increases Adipose Thermogenic Activation to Promote Cold Adaptation.

International journal of molecular sciences · 2019

Study scale: All data are expressed as the mean ± standard error of the mean (SEM).

Abstract only: Open source record

Product or molecular entity relationships

MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Total RNA was isolated using TRIzol (Invitrogen, Carlsbad, CA, USA) and reverse-transcribed using a High-Capacity cDNA Reverse Transcription kit (Takara, Kusatsu, Japan).

Scale or participants

All data are expressed as the mean ± standard error of the mean (SEM).

Key findings

Cold exposure stress causes hypothermia, cognitive impairment, liver injury, and cardiovascular diseases, thereby increasing morbidity and mortality.

Limitations and uncertainty

Cold exposure stress causes hypothermia, cognitive impairment, liver injury, and cardiovascular diseases, thereby increasing morbidity and mortality.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.