Study type: In vitro · Status: Verified against declared source

1,25-dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model.

PloS one · 2014

Study scale: This study was approved by the National Committee of Ethics and National Commission of Scientific Research of the Mexican Institute of Social Security (IMSS, 2008-785-066).

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Diabetic foot ulcers (DFU) are one of the most common diabetes-related cause of hospitalization and often lead to severe infections and poor healing.

Methods

Total RNA from each primary culture was extracted with TRIzol (Gibco, Carlsbad, CA, USA) according to the manufacturer's instructions.

Scale or participants

This study was approved by the National Committee of Ethics and National Commission of Scientific Research of the Mexican Institute of Social Security (IMSS, 2008-785-066).

Key findings

Diabetic foot ulcers (DFU) are one of the most common diabetes-related cause of hospitalization and often lead to severe infections and poor healing.

Limitations and uncertainty

Diabetic foot ulcers (DFU) are one of the most common diabetes-related cause of hospitalization and often lead to severe infections and poor healing.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.