Study type: In vivo/preclinical · Status: Verified against declared source
S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.
Heliyon · 2023
Study scale: Heart sections were incubated with Trias Red-X-conjugate wheat germ agglutinin (WGA-Texas Red) (W21405, Invitrogen, USA) to observe and measure the cross-sectional area of cardiomyocytes.
Abstract only: Open source record
Product or molecular entity relationships
- Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
S14G-humanin (HNG), an analog of the mitochondria-derived peptide humanin, has demonstrated protective effects against various cardiovascular diseases.
Methods
Q.Z., M.C., D.L, B.Z, and S.Z.
Scale or participants
Heart sections were incubated with Trias Red-X-conjugate wheat germ agglutinin (WGA-Texas Red) (W21405, Invitrogen, USA) to observe and measure the cross-sectional area of cardiomyocytes.
Key findings
S14G-humanin (HNG), an analog of the mitochondria-derived peptide humanin, has demonstrated protective effects against various cardiovascular diseases.
Limitations and uncertainty
S14G-humanin (HNG), an analog of the mitochondria-derived peptide humanin, has demonstrated protective effects against various cardiovascular diseases.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.