Study type: In vivo/preclinical · Status: Verified against declared source
spp. utilize the type 3 secretion system to manipulate the VIP/VPAC2 signaling and promote colonization and persistence of the three classicalin the lower respiratory tract.
Frontiers in cellular and infection microbiology · 2023
Study scale: “Whooping cough” or pertussis disease is a re-emerging illness responsible for over 160,000 childhood deaths in 2014 (Yeung et al., 2017), with 30% being in neonates and most being infants under 6 weeks of age (Shi et al., 2021).
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
To evaluate the effects of the VIP/VPAC2 function on Bordetella spp.
Scale or participants
“Whooping cough” or pertussis disease is a re-emerging illness responsible for over 160,000 childhood deaths in 2014 (Yeung et al., 2017), with 30% being in neonates and most being infants under 6 weeks of age (Shi et al., 2021).
Key findings
Bordetella are respiratory pathogens comprised of three classical Bordetella species: B.
Limitations and uncertainty
“Whooping cough” or pertussis disease is a re-emerging illness responsible for over 160,000 childhood deaths in 2014 (Yeung et al., 2017), with 30% being in neonates and most being infants under 6 weeks of age (Shi et al., 2021).
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.