Study type: In vivo/preclinical · Status: Verified against declared source

Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.

PloS one · 2014

Study scale: Not reported

Product or molecular entity relationships

Thymosin Beta-4 (TB500): Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Pulmonary hypertension (PH) is a progressive vascular disease of pulmonary arteries that impedes ejection of blood by the right ventricle.

Methods

Thymosin β4 (Tβ4), a 43-amino acid actin-binding protein encoded by gene Tmsb4x on the X chromosome in mouse, displays abundant protective effects on diverse pathological conditions [1]–[3].

Scale or participants

Not reported in the reviewed source.

Key findings

Pulmonary hypertension (PH) is a progressive vascular disease of pulmonary arteries that impedes ejection of blood by the right ventricle.

Limitations and uncertainty

Pulmonary hypertension (PH) is a progressive vascular disease of pulmonary arteries that impedes ejection of blood by the right ventricle.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.