Study type: In vivo/preclinical · Status: Verified against declared source

Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.

Frontiers in immunology · 2022

Study scale: Plasma levels of Syndecan-1 (A), Endoglin (B), ICAM-1 (C), P-selectin (D), PCSK9 (E), and Angiopoietin-2 (F) at 0 h, 6 h and 18 h after cecal ligation and puncture (CLP).

Abstract only: Open source record

Product or molecular entity relationships

Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Endothelial dysfunction plays a central role in the pathogenesis of sepsis-mediated multiple organ failure.

Methods

BZ conceived and designed the projects.

Scale or participants

Plasma levels of Syndecan-1 (A), Endoglin (B), ICAM-1 (C), P-selectin (D), PCSK9 (E), and Angiopoietin-2 (F) at 0 h, 6 h and 18 h after cecal ligation and puncture (CLP).

Key findings

Endothelial dysfunction plays a central role in the pathogenesis of sepsis-mediated multiple organ failure.

Limitations and uncertainty

Endothelial dysfunction plays a central role in the pathogenesis of sepsis-mediated multiple organ failure.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.